Figure 14

Two-compartment pharmocokinetic model representing the distribution of the contrast agent in plasma and injured spinal cord tissue. The subscripts p and sc denote plasma and spinal cord. [C] _p (t) and [C] _sc (t) are time-dependent concentrations in mmol/L in plasma and spinal cord compartments, respectively. The parameters k _p-sc and k _sc-p denote transfer rate constants in l/min for forward transfer of the contrast agent from plasma-to-spinal cord and reverse transfer from spinal cord-to-plasma compartments, respectively.