Utility of cardiac magnetic resonance in assessing right-sided heart failure in sarcoidosis
© Lønborg et al; licensee BioMed Central Ltd. 2013
Received: 22 May 2012
Accepted: 31 December 2012
Published: 11 January 2013
Cardiac involvement in sarcoidosis is associated with a poor prognosis. In patients with right sided heart failure, differentiating between cor-pulmonale, or cardiac sarcoidosis has important implications to management.
We present the case of a patient with severe but stable pulmonary sarcoidosis and new onset right sided heart failure despite only mild elevations of pulmonary artery pressure. CMR demonstration of extensive right ventricular fibrosis with associated dilatation and hypokinesis was a key finding for prognosis and management of the patient.
Cardiac magnetic resonance (CMR) is the preferred investigation in the diagnosis of cardiac sarcoidosis, allowing assessment of myocardial inflammation and fibrosis, as well as function, in a manner not matched by other technologies.
KeywordsMyocardial sarcoidosis Cardiac magnetic resonance Heart failure Cardiomyopathy
Sarcoidosis is a multi-organ disease characterised by the formation of granulomas. The lungs are most commonly affected. Although cardiac involvement is clinically detected in only 2% of patients, underdiagnosis is a major issue of considerable clinical importance. Recent autopsy data suggest that the heart is, in fact, involved in 20-25% of patients , and is directly responsible for up to 25-80% of deaths attributed to sarcoidosis .
In patients with identified cardiac sarcoidosis the left ventricle (LV) is involved in 98% and the right ventricle (RV) in up to 40%, usually in the context of biventricular involvement . Cardiac sarcoidosis affecting predominantly the RV is rare. In a patient with severe, but stable pulmonary sarcoidosis, we illustrate the important role of CMR in the diagnosis and management of new onset RV failure. CMR is able to identify granulomatous infiltration of the RV, providing evidence for sarcoidosis as the cause of primary RV failure rather than cor pulmonale as the cause of the patients presentation.
The diagnosis of cardiac sarcoidosis is often problematic due to non-specific manifestations, as seen in the present case. These findings include non-specific EKG changes, clinical heart failure, abnormal non-specific echocardiography findings, elevated serum ACE and sudden death . A multimodality approach has traditionally been used to determine cardiac involvement . Dyspnoea from LV heart failure may be attributed to primary pulmonary sarcoidosis. Signs of right heart failure may be put down to pulmonary hypertension secondary to pulmonary sarcoidosis and cor pulmonale. The diagnosis of cardiac sarcoidosis predominantly involving the RV may be even more problematic and may need to be distinguished from arrhythmogenic RV cardiomyopathy. Abnormalities on diagnostic tests such as EKG and echocardiography do not differentiate cardiac sarcoidosis from other cardiac diseases. However, in a patient with sarcoidosis any abnormal findings on EKG or echocardiography should lead to further investigations.
Recently, advanced imaging techniques have been used to identify and characterise cardiac sarcoidosis, with both positron emission tomography (PET) and CMR shown to be superior to the previously recommended scintigraphy [5, 6]. CMR has a sensitivity of 100% and a specificity of 78% for the diagnosis of cardiac sarcoidosis . CMR allows for accurate assessment of cardiac function and comprehensive tissue characterisation. Functional CMR images assess ventricular volumes, function and focal wall motion abnormalities; T2 weighted black blood images can be used to identify oedema and the presence of active inflammation; and delayed gadolinium enhancement images detect scarring with great accuracy . New emerging pre- and postcontrast T1 mapping CMR techniques may provide information regarding interstitial fibrosis and extracellular matrix volume . However, these new techniques are not yet performed routinely in clinical practice. The pattern of oedema or myocardial late enhancement is used to differentiate between non-ischemic and ischemic scarring. Typical cardiac sarcoidosis lesions seen with CMR are focal mid-myocardial or sub-epicardial scarring, whereas sub-endocardial lesions, typical for coronary artery related infarction, is rare with sarcoidosis . CMR is the optimal method of imaging the RV, both in regards to its contractile function, as well as the presence of sarcoid infiltration with late enhancement, as demonstrated by this case. Serial CMR is also useful in the evaluation of anti-inflammatory treatment . The high sensitivity of 18F-FDG PET for active inflammatory lesions is partially countered by the reduced specificity of 18F-FDG in the heart due to the high metabolic rate of the myocardium. However, it is very likely that a complementary role for PET and CMR in the Clinic will be defined in the near future.
Limitations of CMR include significant claustrophobia in up to 5% of patients and contraindication to gadolinium administration in patients with impaired renal function, and inability to image patients with non-MRI compatible pacemakers or AICDs. Furthermore, although CMR is superior to echocardiography in imaging RV structure and function, the thin walled nature of the RV makes delayed enhancement difficult to discriminate from artefact. This is even more problematic when using T2 based imaging sequences to identify oedema in the RV.
Although patients with cardiac sarcoidosis are at risk of adverse cardiac events including ventricular tachycardia (VT) and CMR is predictive of this , the role of prophylactic AICD is not well defined. It is clear that all patients with established VT should receive an AICD and anti-arrhythmic therapy. The patient presented received an AICD due to the extensive nature of RV involvement, with associated dilatation and impaired systolic function. The recorded episode of rapid ventricular tachycardia suggests that this was an appropriate management decision.
CMR is critical in differentiating the cause of new onset right heart failure in a patient with stable pulmonary sarcoidosis, but no significant pulmonary hypertension. Major cardiac events, including sudden cardiac death often occur in patients despite normal EKG and echocardiography. The excellent sensitivity of CMR, its ability to predict cardiac events, and its lack of ionizing radiation has led to the proposal by many experts that CMR should be part of the routine work-up in any patient with sarcoidosis.
Written informed consent was obtained from the patient for publication of this case and any accompanying images. A copy of the written consent is avaliable for review by the Series Editor of this journal.
Angiotensin converting enzyme
Cardiac magnetic resonance
Positron emission tomography
This work was supported by North Shore Heart Research Foundation; Sydney Medical Foundation. JL was supported by Danish Heart Foundation; Danish Cardiovascular Research Academy; Rigshospitalet Research Foundation. GF was supported by a Chapman Fellowship from the Sydney Medical School Foundation.
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